32 entries may sound small by modern standards (current x86 processors have thousands of TLB entries), but it covers 128 KB of memory -- enough for the working set of most 1980s programs. A TLB miss is not catastrophic either; the hardware page walker handles it transparently in about 20 cycles.
Of course, the glue code also has runtime costs. JavaScript objects must be allocated and garbage collected, strings must be re-encoded, structs must be deserialized. Some of this cost is inherent to any bindings system, but much of it is not. This is a pervasive cost that you pay at the boundary between JavaScript and WebAssembly, even when the calls themselves are fast.
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